I have always been wondering why so many European people have allergies. And the bad thing is that I also got kind of allergy in 2014, and since then every year from March to June.
In a recent study, researchers compared 2,712 uniq allergenic proteins or IgE/IgG4-binding protein, and 70,403 metazoan parasite proteins. Through domain discovery and 3D structure analysis, they identified 2,445 parasite proteins that are very similar to allergenic proteins, which includes mainly the EF-hand domains, Profilin and Expansin. They also idenfied the plant-specific Bet v1 domain, which is highly populated with allergens, in the platyhelminth Schistosoma mansoni. SmBv1L (= Smp_146970), annotated as “Putative phosphatidylcholine transfer protein”, is found to be homologous to the plant birch pollen allergen.